SAP Message XS816 - Message cannot be transferred to node & due to connection error (final)

Diagnosis
Due to a technical fault, the system could not set up a connection todestination &V2&. Therefore, the message could not be transferred tonode &V1&.

System Response
The system was unable to transfer the message.
Additional information of the node used (in the system language of thenode):
V4
Check the connection from the SAP system to node &V1&. Perhaps the nodeis not assigned to the correct destination. If so, correct this inCustomizing.
In production operation, it is advisable to reroute provisionally toanother node.
You should therefore notify your system administrator.